Industrial internet platforms serve as a key driver for advancing the digital transformation of the manufacturing industry and an important arena for manufacturing enterprises to conduct integrated innovation. Currently， the academic community’s attention to the co-innovation of enterprises participating in industrial internet platforms was relatively lacking， and it hadn’t fully revealed the concept definition， driving mechanism， and governance strategy of co-innovation of enterprises participating in the context of industrial internet platforms. Based on the theories of symbiosis and resource orchestration， it investigated 184 platform participating manufacturing enterprises and employed the fuzzy set qualitative comparative analysis （fsQCA） method to explore various interactive paths of co-innovation in manufacturing enterprises under the interaction of six selected antecedent conditions across three dimensions of local digital environment， empowering subjects of platform， and empowering objects of platform. It innovatively defined the connotation of co-innovation in manufacturing enterprises in industrial internet platforms from the perspectives of “integration” and “smoothness” and scientifically measured them. There are four paths for participating manufacturing enterprises in industrial internet platforms to achieve high levels of co-innovation， namely platform empowering subject-object synergy type， platform-driven object self-empowerment type， environment and platform subject drive type， and environment and platform object matching type. It expands the theoretical understanding of co-innovation in manufacturing enterprises in the industrial internet platform context and provides recommendations for the practical implementation of co-innovation in manufacturing enterprises.