Currently， the impact of innovation openness on innovation performance did not come to a consistent conclusion theoretically or practically. Hence， the open innovation paradox came up. Besides， the situational factors that may have influence on the above relationship were also lack of consensus. Therefore， it used meta-analysis method to conduct a re-analysis with 141 448 research samples from 82 independent studies. A more integrated and robust conclusion was achieved. The results show that there is a significant medium-intensity positive relationship between openness and innovation performance， and open breadth and open depth also have significant positive impact on innovation performance. Five situational factors including firm size， extant industry， uncertainty avoidance and collective-individualism cultural tendency that belongs to national cultural factors， national economy entity produce moderating effects on the above relationship. Under the background of collectivist cultural orientation， the influence of SMEs' openness on innovation performance is more significant. While in traditional manufacturing or service industry， open depth has more significant impact on innovation performance； the impact of the openness breadth of high-tech enterprises on innovation performance is more pronounced； promoting impact extent of openness on innovation performances in emerging economy is larger than in other national economy entities. The above conclusions are of referential significance for firms to evaluate the importance of open innovation and take targeted management measures.