Under the realistic demand of high-quality economic development， further improving regional innovation efficiency is of great significance for China to accelerate its construction into a powerful modern socialist country. Based on the panel data of the provincial area in Chinese mainland， it used the method of spatial econometric analysis to observe whether digital economy promotes regional innovation efficiency through spatial knowledge spillover， after measuring the development level of digital economy and regional innovation efficiency by adopting panel entropy method and stochastic frontier analysis respectively. It finds that the development of digital economy in China promotes the increase of regional innovation efficiency significantly， and also leads to the improvement of innovation efficiency in other regions through spatial spillover effect. The results are still robust considering different spatial weight matrices. The conclusions provide policy inspiration for making full use of the spatial spillover effects of digital economy and promoting the overall improvement of regional innovation efficiency.