Digital intelligence transformation serves as a crucial pathway for specialized and sophisticated enterprises to enhance their innovation resilience and response complex environments in the VUCA era. It empirically examined the empowerment effect and operational mechanism of digital intelligence transformation on innovation resilience of such enterprises， based on the national-level specialized and sophisticated “Little Giant” enterprises listed on China’s A-share market from 2013 to 2022. The findings reveal that digital intelligence transformation significantly enhances innovation resilience of the specialized and sophisticated enterprises. Mechanism tests indicate that this transformation boosts innovation resilience by promoting collaborative innovation， increasing risk-taking capacity， and strengthening technological advantages. Heterogeneity analysis shows that contextual factors， including the degree of strategic implementation， industry concentration， and regional digital infrastructure levels， significantly amplify the positive impact of digital intelligence transformation on innovation resilience. It enriches the theoretical understanding of the relationship between digital intelligence transformation and innovation resilience from a micro-mechanism perspective， and also provides policy and management insights for the specialized and sophisticated enterprises to systematically enhance their innovation resilience through digital intelligence transformation.